Datasetchrom
PhenotypeNoPhenotypeAvailable
Upregulated in classna_neg
GeneSetREACTOME_METABOLISM_OF_RNA
Enrichment Score (ES)-0.35440958
Normalized Enrichment Score (NES)-1.757454
Nominal p-value0.0
FDR q-value0.015161266
FWER p-Value0.277
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME_METABOLISM_OF_RNA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SNRPFSNRPF
Entrez,  Source
small nuclear ribonucleoprotein polypeptide F1102.029-0.0165No
2PHAX1831.594-0.0249No
3PSME2PSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)2381.412-0.0293No
4PATL12541.381-0.0219No
5PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)3401.183-0.0380No
6NUP50NUP50
Entrez,  Source
nucleoporin 50kDa3831.108-0.0413No
7HNRNPD4311.023-0.0470No
8ELAVL1ELAVL1
Entrez,  Source
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)4610.992-0.0473No
9PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 104740.974-0.0425No
10EXOSC2EXOSC2
Entrez,  Source
exosome component 24820.962-0.0362No
11PSME4PSME4
Entrez,  Source
proteasome (prosome, macropain) activator subunit 45950.851-0.0636No
12RAE1RAE1
Entrez,  Source
RAE1 RNA export 1 homolog (S. pombe)6460.792-0.0723No
13EIF4A2EIF4A2
Entrez,  Source
eukaryotic translation initiation factor 4A, isoform 27370.706-0.0941No
14PSMB4PSMB4
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 47800.674-0.1013No
15KHSRPKHSRP
Entrez,  Source
KH-type splicing regulatory protein (FUSE binding protein 2)8140.643-0.1059No
16EXOSC6EXOSC6
Entrez,  Source
exosome component 68730.602-0.1187No
17LSM6LSM6
Entrez,  Source
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)8940.585-0.1198No
18EXOSC3EXOSC3
Entrez,  Source
exosome component 38950.584-0.1147No
19NUPL1NUPL1
Entrez,  Source
nucleoporin like 19070.577-0.1130No
20PPP2R1APPP2R1A
Entrez,  Source
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform9140.569-0.1099No
21EXOSC1EXOSC1
Entrez,  Source
exosome component 19780.535-0.1248No
22EXOSC4EXOSC4
Entrez,  Source
exosome component 410010.522-0.1271No
23PSMC3PSMC3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 310140.515-0.1263No
24RPL13RPL13
Entrez,  Source
ribosomal protein L1310210.511-0.1237No
25AAASAAAS
Entrez,  Source
achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)10470.496-0.1271No
26DIS310810.476-0.1332No
27NUP37NUP37
Entrez,  Source
nucleoporin 37kDa11020.460-0.1354No
28EIF4A311100.455-0.1336No
29EXOSC8EXOSC8
Entrez,  Source
exosome component 811160.450-0.1312No
30PSMB6PSMB6
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 611170.450-0.1272No
31PSMA5PSMA5
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 511200.447-0.1239No
32RBM8ARBM8A
Entrez,  Source
RNA binding motif protein 8A11260.445-0.1216No
33NUP88NUP88
Entrez,  Source
nucleoporin 88kDa11290.444-0.1183No
34NUP85NUP85
Entrez,  Source
nucleoporin 85kDa11750.416-0.1287No
35NUP133NUP133
Entrez,  Source
nucleoporin 133kDa12030.404-0.1335No
36NUP214NUP214
Entrez,  Source
nucleoporin 214kDa12090.403-0.1316No
37TNPO1TNPO1
Entrez,  Source
transportin 112220.397-0.1318No
38PSMB2PSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 212430.379-0.1347No
39NUP93NUP93
Entrez,  Source
nucleoporin 93kDa12680.362-0.1390No
40NUP188NUP188
Entrez,  Source
nucleoporin 188kDa12730.360-0.1371No
41NCBP1NCBP1
Entrez,  Source
nuclear cap binding protein subunit 1, 80kDa12920.348-0.1396No
42RPL32RPL32
Entrez,  Source
ribosomal protein L3212990.345-0.1385No
43NUP205NUP205
Entrez,  Source
nucleoporin 205kDa13200.330-0.1418No
44EXOSC5EXOSC5
Entrez,  Source
exosome component 513450.313-0.1466No
45NUP107NUP107
Entrez,  Source
nucleoporin 107kDa13520.310-0.1457No
46PSMA6PSMA6
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 613980.283-0.1572No
47XPO1XPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)14040.278-0.1564No
48ANP32AANP32A
Entrez,  Source
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A14120.275-0.1561No
49RNPS1RNPS1
Entrez,  Source
RNA binding protein S1, serine-rich domain14210.268-0.1563No
50NUP155NUP155
Entrez,  Source
nucleoporin 155kDa14380.259-0.1590No
51EXOSC9EXOSC9
Entrez,  Source
exosome component 914750.232-0.1682No
52NUP54NUP54
Entrez,  Source
nucleoporin 54kDa14800.228-0.1674No
53EXOSC7EXOSC7
Entrez,  Source
exosome component 714830.227-0.1660No
54PSMA3PSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 314870.225-0.1650No
55SEH1LSEH1L
Entrez,  Source
SEH1-like (S. cerevisiae)15070.207-0.1691No
56PSMA4PSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 415180.200-0.1705No
57YWHAZYWHAZ
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide15190.199-0.1687No
58LSM4LSM4
Entrez,  Source
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)15330.188-0.1711No
59PSMB1PSMB1
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 115710.168-0.1812No
60NUP62NUP62
Entrez,  Source
nucleoporin 62kDa15750.166-0.1806No
61PPP2CAPPP2CA
Entrez,  Source
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform15930.158-0.1845No
62EIF4A1EIF4A1
Entrez,  Source
eukaryotic translation initiation factor 4A, isoform 115940.157-0.1832No
63RPL26L1RPL26L1
Entrez,  Source
ribosomal protein L26-like 116070.147-0.1856No
64ETF1ETF1
Entrez,  Source
eukaryotic translation termination factor 116620.113-0.2014No
65HSPA8HSPA8
Entrez,  Source
heat shock 70kDa protein 816640.113-0.2008No
66SNRPD1SNRPD1
Entrez,  Source
small nuclear ribonucleoprotein D1 polypeptide 16kDa16740.106-0.2026No
67SNRPGSNRPG
Entrez,  Source
small nuclear ribonucleoprotein polypeptide G16940.094-0.2077No
68NUPL2NUPL2
Entrez,  Source
nucleoporin like 216970.093-0.2075No
69TPRTPR
Entrez,  Source
translocated promoter region (to activated MET oncogene)17260.075-0.2156No
70PSMB3PSMB3
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 317310.073-0.2162No
71RPS27ARPS27A
Entrez,  Source
ribosomal protein S27a17390.066-0.2178No
72PSMC6PSMC6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 617590.054-0.2233No
73PSMC5PSMC5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 517840.038-0.2304No
74RPL12RPL12
Entrez,  Source
ribosomal protein L1217850.038-0.2301No
75PSMA1PSMA1
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 118110.028-0.2376No
76PABPC1PABPC1
Entrez,  Source
poly(A) binding protein, cytoplasmic 118130.026-0.2377No
77PSMD14PSMD14
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1418320.013-0.2432No
78WDR77WDR77
Entrez,  Source
WD repeat domain 771863-0.006-0.2525No
79PSMA2PSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 21911-0.047-0.2668No
80NCBP2NCBP2
Entrez,  Source
nuclear cap binding protein subunit 2, 20kDa1933-0.062-0.2728No
81RPL15RPL15
Entrez,  Source
ribosomal protein L151943-0.068-0.2750No
82RPL10ARPL10A
Entrez,  Source
ribosomal protein L10a1954-0.075-0.2774No
83HSPB1HSPB1
Entrez,  Source
heat shock 27kDa protein 11958-0.079-0.2777No
84EIF4EEIF4E
Entrez,  Source
eukaryotic translation initiation factor 4E1971-0.086-0.2806No
85MAGOHMAGOH
Entrez,  Source
mago-nashi homolog, proliferation-associated (Drosophila)1973-0.086-0.2802No
86UPF3BUPF3B
Entrez,  Source
UPF3 regulator of nonsense transcripts homolog B (yeast)1979-0.089-0.2810No
87NUP43NUP43
Entrez,  Source
nucleoporin 43kDa1986-0.096-0.2820No
88YWHABYWHAB
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1989-0.098-0.2818No
89RPL18RPL18
Entrez,  Source
ribosomal protein L182012-0.114-0.2876No
90PSMC4PSMC4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 42015-0.115-0.2872No
91PSMD6PSMD6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 62028-0.127-0.2899No
92PSMD1PSMD1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12033-0.133-0.2899No
93PSMD11PSMD11
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 112082-0.168-0.3034No
94SNRPD3SNRPD3
Entrez,  Source
small nuclear ribonucleoprotein D3 polypeptide 18kDa2090-0.174-0.3041No
95PSMD2PSMD2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 22091-0.175-0.3025No
96PSMB7PSMB7
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 72141-0.209-0.3160No
97PSMC1PSMC1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 12163-0.220-0.3206No
98PSMA7PSMA7
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 72167-0.223-0.3196No
99RPS24RPS24
Entrez,  Source
ribosomal protein S242211-0.253-0.3307No
100PSMD3PSMD3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 32216-0.256-0.3297No
101PARNPARN
Entrez,  Source
poly(A)-specific ribonuclease (deadenylation nuclease)2230-0.266-0.3314No
102PSMD12PSMD12
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 122232-0.268-0.3294No
103RPL5RPL5
Entrez,  Source
ribosomal protein L52234-0.269-0.3273No
104PSMD13PSMD13
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 132239-0.272-0.3262No
105SNRPESNRPE
Entrez,  Source
small nuclear ribonucleoprotein polypeptide E2256-0.284-0.3287No
106SMN1SMN1
Entrez,  Source
survival of motor neuron 1, telomeric2307-0.309-0.3416No
107RPL28RPL28
Entrez,  Source
ribosomal protein L282309-0.310-0.3391No
108PSMD7PSMD7
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)2311-0.312-0.3367No
109LSM1LSM1
Entrez,  Source
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)2330-0.323-0.3395No
110PSMB5PSMB5
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 52356-0.336-0.3443No
111PSMD8PSMD8
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 82368-0.349-0.3447No
112RPL11RPL11
Entrez,  Source
ribosomal protein L112370-0.350-0.3419No
113RPL23ARPL23A
Entrez,  Source
ribosomal protein L23a2397-0.373-0.3468No
114RPL7ARPL7A
Entrez,  Source
ribosomal protein L7a2402-0.376-0.3447No
115RQCD1RQCD1
Entrez,  Source
RCD1 required for cell differentiation1 homolog (S. pombe)2405-0.379-0.3420No
116SNRPD2SNRPD2
Entrez,  Source
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa2407-0.379-0.3390No
117RPL13ARPL13A
Entrez,  Source
ribosomal protein L13a2427-0.399-0.3414No
118PSMD4PSMD4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 42456-0.426-0.3464No
119RPL29RPL29
Entrez,  Source
ribosomal protein L292466-0.433-0.3454No
120RPL21RPL21
Entrez,  Source
ribosomal protein L212496-0.455-0.3504Yes
121RPL8RPL8
Entrez,  Source
ribosomal protein L82503-0.460-0.3482Yes
122PSMC2PSMC2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 22509-0.467-0.3457Yes
123RPL27RPL27
Entrez,  Source
ribosomal protein L272512-0.469-0.3422Yes
124RPL14RPL14
Entrez,  Source
ribosomal protein L142534-0.488-0.3444Yes
125NUP153NUP153
Entrez,  Source
nucleoporin 153kDa2537-0.489-0.3408Yes
126RANBP2RANBP2
Entrez,  Source
RAN binding protein 22542-0.493-0.3377Yes
127DDX6DDX6
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 62552-0.498-0.3361Yes
128RPL6RPL6
Entrez,  Source
ribosomal protein L62569-0.516-0.3366Yes
129RPL17RPL17
Entrez,  Source
ribosomal protein L172574-0.518-0.3333Yes
130RPL18ARPL18A
Entrez,  Source
ribosomal protein L18a2598-0.538-0.3357Yes
131EDC4EDC4
Entrez,  Source
enhancer of mRNA decapping 42624-0.566-0.3385Yes
132RPL4RPL4
Entrez,  Source
ribosomal protein L42632-0.572-0.3357Yes
133RPL27ARPL27A
Entrez,  Source
ribosomal protein L27a2635-0.574-0.3313Yes
134LSM3LSM3
Entrez,  Source
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)2637-0.576-0.3265Yes
135PSMB8PSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)2639-0.577-0.3218Yes
136PRMT5PRMT5
Entrez,  Source
protein arginine methyltransferase 52648-0.587-0.3191Yes
137RPS8RPS8
Entrez,  Source
ribosomal protein S82658-0.592-0.3167Yes
138RPL35RPL35
Entrez,  Source
ribosomal protein L352691-0.615-0.3213Yes
139CNOT7CNOT7
Entrez,  Source
CCR4-NOT transcription complex, subunit 72708-0.629-0.3207Yes
140GEMIN4GEMIN4
Entrez,  Source
gem (nuclear organelle) associated protein 42719-0.642-0.3182Yes
141NUP210NUP210
Entrez,  Source
nucleoporin 210kDa2747-0.665-0.3208Yes
142RPL9RPL9
Entrez,  Source
ribosomal protein L92754-0.671-0.3167Yes
143RPL7RPL7
Entrez,  Source
ribosomal protein L72766-0.684-0.3142Yes
144RPS15RPS15
Entrez,  Source
ribosomal protein S152780-0.712-0.3120Yes
145RPS7RPS7
Entrez,  Source
ribosomal protein S72811-0.746-0.3147Yes
146RPS5RPS5
Entrez,  Source
ribosomal protein S52832-0.773-0.3142Yes
147RPL30RPL30
Entrez,  Source
ribosomal protein L302838-0.780-0.3089Yes
148RPSARPSA
Entrez,  Source
ribosomal protein SA2843-0.783-0.3033Yes
149RPS3ARPS3A
Entrez,  Source
ribosomal protein S3A2847-0.786-0.2973Yes
150RPL24RPL24
Entrez,  Source
ribosomal protein L242863-0.805-0.2949Yes
151RPL34RPL34
Entrez,  Source
ribosomal protein L342865-0.809-0.2881Yes
152RPL23RPL23
Entrez,  Source
ribosomal protein L232891-0.831-0.2886Yes
153NUP35NUP35
Entrez,  Source
nucleoporin 35kDa2894-0.835-0.2819Yes
154RPL35ARPL35A
Entrez,  Source
ribosomal protein L35a2898-0.838-0.2754Yes
155RPL3RPL3
Entrez,  Source
ribosomal protein L32902-0.843-0.2690Yes
156RPLP0RPLP0
Entrez,  Source
ribosomal protein, large, P02912-0.858-0.2642Yes
157RPL36RPL36
Entrez,  Source
ribosomal protein L362920-0.867-0.2588Yes
158RPS13RPS13
Entrez,  Source
ribosomal protein S132928-0.875-0.2533Yes
159RPS9RPS9
Entrez,  Source
ribosomal protein S92930-0.876-0.2459Yes
160RPL22RPL22
Entrez,  Source
ribosomal protein L222942-0.889-0.2415Yes
161RPS10RPS10
Entrez,  Source
ribosomal protein S102958-0.909-0.2382Yes
162RPL10RPL10
Entrez,  Source
ribosomal protein L102961-0.912-0.2308Yes
163EIF4G1EIF4G1
Entrez,  Source
eukaryotic translation initiation factor 4 gamma, 12964-0.915-0.2234Yes
164RPL31RPL31
Entrez,  Source
ribosomal protein L312965-0.916-0.2153Yes
165RPS25RPS25
Entrez,  Source
ribosomal protein S252976-0.938-0.2102Yes
166RPS29RPS29
Entrez,  Source
ribosomal protein S292989-0.964-0.2055Yes
167RPS6RPS6
Entrez,  Source
ribosomal protein S62990-0.965-0.1970Yes
168RPS3RPS3
Entrez,  Source
ribosomal protein S32992-0.968-0.1888Yes
169RPS11RPS11
Entrez,  Source
ribosomal protein S112996-0.971-0.1812Yes
170UPF2UPF2
Entrez,  Source
UPF2 regulator of nonsense transcripts homolog (yeast)3002-0.983-0.1741Yes
171PSMD10PSMD10
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 103006-0.992-0.1663Yes
172RPS14RPS14
Entrez,  Source
ribosomal protein S143010-0.996-0.1585Yes
173FAUFAU
Entrez,  Source
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S303011-0.998-0.1497Yes
174RPS23RPS23
Entrez,  Source
ribosomal protein S233028-1.022-0.1457Yes
175RPL38RPL38
Entrez,  Source
ribosomal protein L383041-1.055-0.1402Yes
176RPS18RPS18
Entrez,  Source
ribosomal protein S183053-1.078-0.1342Yes
177RPS16RPS16
Entrez,  Source
ribosomal protein S163066-1.097-0.1283Yes
178RPS2RPS2
Entrez,  Source
ribosomal protein S23076-1.109-0.1213Yes
179RPS19RPS19
Entrez,  Source
ribosomal protein S193083-1.121-0.1133Yes
180RPL37ARPL37A
Entrez,  Source
ribosomal protein L37a3088-1.125-0.1047Yes
181RPS4XRPS4X
Entrez,  Source
ribosomal protein S4, X-linked3097-1.137-0.0972Yes
182RPS21RPS21
Entrez,  Source
ribosomal protein S213111-1.163-0.0910Yes
183DDX20DDX20
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 203117-1.178-0.0822Yes
184LSM2LSM2
Entrez,  Source
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)3148-1.235-0.0807Yes
185RPS12RPS12
Entrez,  Source
ribosomal protein S123149-1.236-0.0699Yes
186PSMD5PSMD5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 53166-1.275-0.0636Yes
187RPS28RPS28
Entrez,  Source
ribosomal protein S283187-1.329-0.0582Yes
188RPLP2RPLP2
Entrez,  Source
ribosomal protein, large, P23209-1.380-0.0526Yes
189RPS15ARPS15A
Entrez,  Source
ribosomal protein S15a3238-1.448-0.0486Yes
190RPL19RPL19
Entrez,  Source
ribosomal protein L193243-1.476-0.0369Yes
191RPS26RPS26
Entrez,  Source
ribosomal protein S263292-1.635-0.0375Yes
192RPS20RPS20
Entrez,  Source
ribosomal protein S203295-1.644-0.0237Yes
193TNKS1BP1TNKS1BP1
Entrez,  Source
tankyrase 1 binding protein 1, 182kDa3349-1.972-0.0229Yes
194RPS27RPS27
Entrez,  Source
ribosomal protein S27 (metallopanstimulin 1)3354-1.987-0.0066Yes
195RPLP1RPLP1
Entrez,  Source
ribosomal protein, large, P13377-2.4230.0078Yes
Table: GSEA details [plain text format]



Fig 2: REACTOME_METABOLISM_OF_RNA: Random ES distribution   
Gene set null distribution of ES for REACTOME_METABOLISM_OF_RNA