Datasetchrom
PhenotypeNoPhenotypeAvailable
Upregulated in classna_neg
GeneSetREACTOME_METABOLISM_OF_MRNA
Enrichment Score (ES)-0.4126088
Normalized Enrichment Score (NES)-1.9804851
Nominal p-value0.0
FDR q-value0.0013064737
FWER p-Value0.023
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME_METABOLISM_OF_MRNA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1PSME2PSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)2381.412-0.0588No
2PATL12541.381-0.0491No
3PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)3401.183-0.0631No
4HNRNPD4311.023-0.0803No
5ELAVL1ELAVL1
Entrez,  Source
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)4610.992-0.0790No
6PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 104740.974-0.0726No
7EXOSC2EXOSC2
Entrez,  Source
exosome component 24820.962-0.0648No
8PSME4PSME4
Entrez,  Source
proteasome (prosome, macropain) activator subunit 45950.851-0.0906No
9EIF4A2EIF4A2
Entrez,  Source
eukaryotic translation initiation factor 4A, isoform 27370.706-0.1267No
10PSMB4PSMB4
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 47800.674-0.1327No
11KHSRPKHSRP
Entrez,  Source
KH-type splicing regulatory protein (FUSE binding protein 2)8140.643-0.1363No
12EXOSC6EXOSC6
Entrez,  Source
exosome component 68730.602-0.1479No
13LSM6LSM6
Entrez,  Source
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)8940.585-0.1480No
14EXOSC3EXOSC3
Entrez,  Source
exosome component 38950.584-0.1420No
15PPP2R1APPP2R1A
Entrez,  Source
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform9140.569-0.1417No
16EXOSC1EXOSC1
Entrez,  Source
exosome component 19780.535-0.1556No
17EXOSC4EXOSC4
Entrez,  Source
exosome component 410010.522-0.1570No
18PSMC3PSMC3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 310140.515-0.1553No
19RPL13RPL13
Entrez,  Source
ribosomal protein L1310210.511-0.1519No
20DIS310810.476-0.1652No
21EIF4A311100.455-0.1691No
22EXOSC8EXOSC8
Entrez,  Source
exosome component 811160.450-0.1660No
23PSMB6PSMB6
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 611170.450-0.1613No
24PSMA5PSMA5
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 511200.447-0.1573No
25RBM8ARBM8A
Entrez,  Source
RNA binding motif protein 8A11260.445-0.1543No
26NUP214NUP214
Entrez,  Source
nucleoporin 214kDa12090.403-0.1754No
27TNPO1TNPO1
Entrez,  Source
transportin 112220.397-0.1750No
28PSMB2PSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 212430.379-0.1772No
29NCBP1NCBP1
Entrez,  Source
nuclear cap binding protein subunit 1, 80kDa12920.348-0.1884No
30RPL32RPL32
Entrez,  Source
ribosomal protein L3212990.345-0.1867No
31EXOSC5EXOSC5
Entrez,  Source
exosome component 513450.313-0.1974No
32PSMA6PSMA6
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 613980.283-0.2105No
33XPO1XPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)14040.278-0.2091No
34ANP32AANP32A
Entrez,  Source
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A14120.275-0.2085No
35RNPS1RNPS1
Entrez,  Source
RNA binding protein S1, serine-rich domain14210.268-0.2082No
36EXOSC9EXOSC9
Entrez,  Source
exosome component 914750.232-0.2221No
37EXOSC7EXOSC7
Entrez,  Source
exosome component 714830.227-0.2219No
38PSMA3PSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 314870.225-0.2205No
39PSMA4PSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 415180.200-0.2277No
40YWHAZYWHAZ
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide15190.199-0.2256No
41LSM4LSM4
Entrez,  Source
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)15330.188-0.2277No
42PSMB1PSMB1
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 115710.168-0.2374No
43PPP2CAPPP2CA
Entrez,  Source
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform15930.158-0.2422No
44EIF4A1EIF4A1
Entrez,  Source
eukaryotic translation initiation factor 4A, isoform 115940.157-0.2406No
45RPL26L1RPL26L1
Entrez,  Source
ribosomal protein L26-like 116070.147-0.2428No
46ETF1ETF1
Entrez,  Source
eukaryotic translation termination factor 116620.113-0.2583No
47HSPA8HSPA8
Entrez,  Source
heat shock 70kDa protein 816640.113-0.2574No
48PSMB3PSMB3
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 317310.073-0.2770No
49RPS27ARPS27A
Entrez,  Source
ribosomal protein S27a17390.066-0.2785No
50PSMC6PSMC6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 617590.054-0.2838No
51PSMC5PSMC5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 517840.038-0.2908No
52RPL12RPL12
Entrez,  Source
ribosomal protein L1217850.038-0.2904No
53PSMA1PSMA1
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 118110.028-0.2978No
54PABPC1PABPC1
Entrez,  Source
poly(A) binding protein, cytoplasmic 118130.026-0.2979No
55PSMD14PSMD14
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1418320.013-0.3033No
56PSMA2PSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 21911-0.047-0.3268No
57NCBP2NCBP2
Entrez,  Source
nuclear cap binding protein subunit 2, 20kDa1933-0.062-0.3327No
58RPL15RPL15
Entrez,  Source
ribosomal protein L151943-0.068-0.3347No
59RPL10ARPL10A
Entrez,  Source
ribosomal protein L10a1954-0.075-0.3370No
60HSPB1HSPB1
Entrez,  Source
heat shock 27kDa protein 11958-0.079-0.3372No
61EIF4EEIF4E
Entrez,  Source
eukaryotic translation initiation factor 4E1971-0.086-0.3400No
62MAGOHMAGOH
Entrez,  Source
mago-nashi homolog, proliferation-associated (Drosophila)1973-0.086-0.3394No
63UPF3BUPF3B
Entrez,  Source
UPF3 regulator of nonsense transcripts homolog B (yeast)1979-0.089-0.3400No
64YWHABYWHAB
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1989-0.098-0.3418No
65RPL18RPL18
Entrez,  Source
ribosomal protein L182012-0.114-0.3474No
66PSMC4PSMC4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 42015-0.115-0.3468No
67PSMD6PSMD6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 62028-0.127-0.3492No
68PSMD1PSMD1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12033-0.133-0.3490No
69PSMD11PSMD11
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 112082-0.168-0.3621No
70PSMD2PSMD2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 22091-0.175-0.3628No
71PSMB7PSMB7
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 72141-0.209-0.3757No
72PSMC1PSMC1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 12163-0.220-0.3799No
73PSMA7PSMA7
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 72167-0.223-0.3785No
74RPS24RPS24
Entrez,  Source
ribosomal protein S242211-0.253-0.3892No
75PSMD3PSMD3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 32216-0.256-0.3878No
76PARNPARN
Entrez,  Source
poly(A)-specific ribonuclease (deadenylation nuclease)2230-0.266-0.3890No
77PSMD12PSMD12
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 122232-0.268-0.3866No
78RPL5RPL5
Entrez,  Source
ribosomal protein L52234-0.269-0.3841No
79PSMD13PSMD13
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 132239-0.272-0.3825No
80RPL28RPL28
Entrez,  Source
ribosomal protein L282309-0.310-0.4006No
81PSMD7PSMD7
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)2311-0.312-0.3977No
82LSM1LSM1
Entrez,  Source
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)2330-0.323-0.3999No
83PSMB5PSMB5
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 52356-0.336-0.4041No
84PSMD8PSMD8
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 82368-0.349-0.4039No
85RPL11RPL11
Entrez,  Source
ribosomal protein L112370-0.350-0.4006No
86RPL23ARPL23A
Entrez,  Source
ribosomal protein L23a2397-0.373-0.4047No
87RPL7ARPL7A
Entrez,  Source
ribosomal protein L7a2402-0.376-0.4021No
88RQCD1RQCD1
Entrez,  Source
RCD1 required for cell differentiation1 homolog (S. pombe)2405-0.379-0.3988No
89RPL13ARPL13A
Entrez,  Source
ribosomal protein L13a2427-0.399-0.4011No
90PSMD4PSMD4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 42456-0.426-0.4054No
91RPL29RPL29
Entrez,  Source
ribosomal protein L292466-0.433-0.4037No
92RPL21RPL21
Entrez,  Source
ribosomal protein L212496-0.455-0.4079Yes
93RPL8RPL8
Entrez,  Source
ribosomal protein L82503-0.460-0.4050Yes
94PSMC2PSMC2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 22509-0.467-0.4017Yes
95RPL27RPL27
Entrez,  Source
ribosomal protein L272512-0.469-0.3975Yes
96RPL14RPL14
Entrez,  Source
ribosomal protein L142534-0.488-0.3989Yes
97DDX6DDX6
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 62552-0.498-0.3990Yes
98RPL6RPL6
Entrez,  Source
ribosomal protein L62569-0.516-0.3986Yes
99RPL17RPL17
Entrez,  Source
ribosomal protein L172574-0.518-0.3945Yes
100RPL18ARPL18A
Entrez,  Source
ribosomal protein L18a2598-0.538-0.3960Yes
101EDC4EDC4
Entrez,  Source
enhancer of mRNA decapping 42624-0.566-0.3979Yes
102RPL4RPL4
Entrez,  Source
ribosomal protein L42632-0.572-0.3941Yes
103RPL27ARPL27A
Entrez,  Source
ribosomal protein L27a2635-0.574-0.3888Yes
104LSM3LSM3
Entrez,  Source
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)2637-0.576-0.3832Yes
105PSMB8PSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)2639-0.577-0.3775Yes
106RPS8RPS8
Entrez,  Source
ribosomal protein S82658-0.592-0.3769Yes
107RPL35RPL35
Entrez,  Source
ribosomal protein L352691-0.615-0.3805Yes
108CNOT7CNOT7
Entrez,  Source
CCR4-NOT transcription complex, subunit 72708-0.629-0.3789Yes
109RPL9RPL9
Entrez,  Source
ribosomal protein L92754-0.671-0.3858Yes
110RPL7RPL7
Entrez,  Source
ribosomal protein L72766-0.684-0.3821Yes
111RPS15RPS15
Entrez,  Source
ribosomal protein S152780-0.712-0.3788Yes
112RPS7RPS7
Entrez,  Source
ribosomal protein S72811-0.746-0.3803Yes
113RPS5RPS5
Entrez,  Source
ribosomal protein S52832-0.773-0.3785Yes
114RPL30RPL30
Entrez,  Source
ribosomal protein L302838-0.780-0.3720Yes
115RPSARPSA
Entrez,  Source
ribosomal protein SA2843-0.783-0.3651Yes
116RPS3ARPS3A
Entrez,  Source
ribosomal protein S3A2847-0.786-0.3579Yes
117RPL24RPL24
Entrez,  Source
ribosomal protein L242863-0.805-0.3542Yes
118RPL34RPL34
Entrez,  Source
ribosomal protein L342865-0.809-0.3462Yes
119RPL23RPL23
Entrez,  Source
ribosomal protein L232891-0.831-0.3453Yes
120RPL35ARPL35A
Entrez,  Source
ribosomal protein L35a2898-0.838-0.3385Yes
121RPL3RPL3
Entrez,  Source
ribosomal protein L32902-0.843-0.3307Yes
122RPLP0RPLP0
Entrez,  Source
ribosomal protein, large, P02912-0.858-0.3246Yes
123RPL36RPL36
Entrez,  Source
ribosomal protein L362920-0.867-0.3178Yes
124RPS13RPS13
Entrez,  Source
ribosomal protein S132928-0.875-0.3109Yes
125RPS9RPS9
Entrez,  Source
ribosomal protein S92930-0.876-0.3022Yes
126RPL22RPL22
Entrez,  Source
ribosomal protein L222942-0.889-0.2964Yes
127RPS10RPS10
Entrez,  Source
ribosomal protein S102958-0.909-0.2916Yes
128RPL10RPL10
Entrez,  Source
ribosomal protein L102961-0.912-0.2828Yes
129EIF4G1EIF4G1
Entrez,  Source
eukaryotic translation initiation factor 4 gamma, 12964-0.915-0.2739Yes
130RPL31RPL31
Entrez,  Source
ribosomal protein L312965-0.916-0.2645Yes
131RPS25RPS25
Entrez,  Source
ribosomal protein S252976-0.938-0.2578Yes
132RPS29RPS29
Entrez,  Source
ribosomal protein S292989-0.964-0.2516Yes
133RPS6RPS6
Entrez,  Source
ribosomal protein S62990-0.965-0.2416Yes
134RPS3RPS3
Entrez,  Source
ribosomal protein S32992-0.968-0.2319Yes
135RPS11RPS11
Entrez,  Source
ribosomal protein S112996-0.971-0.2228Yes
136UPF2UPF2
Entrez,  Source
UPF2 regulator of nonsense transcripts homolog (yeast)3002-0.983-0.2142Yes
137PSMD10PSMD10
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 103006-0.992-0.2048Yes
138RPS14RPS14
Entrez,  Source
ribosomal protein S143010-0.996-0.1955Yes
139FAUFAU
Entrez,  Source
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S303011-0.998-0.1851Yes
140RPS23RPS23
Entrez,  Source
ribosomal protein S233028-1.022-0.1795Yes
141RPL38RPL38
Entrez,  Source
ribosomal protein L383041-1.055-0.1723Yes
142RPS18RPS18
Entrez,  Source
ribosomal protein S183053-1.078-0.1645Yes
143RPS16RPS16
Entrez,  Source
ribosomal protein S163066-1.097-0.1569Yes
144RPS2RPS2
Entrez,  Source
ribosomal protein S23076-1.109-0.1482Yes
145RPS19RPS19
Entrez,  Source
ribosomal protein S193083-1.121-0.1385Yes
146RPL37ARPL37A
Entrez,  Source
ribosomal protein L37a3088-1.125-0.1281Yes
147RPS4XRPS4X
Entrez,  Source
ribosomal protein S4, X-linked3097-1.137-0.1188Yes
148RPS21RPS21
Entrez,  Source
ribosomal protein S213111-1.163-0.1108Yes
149LSM2LSM2
Entrez,  Source
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)3148-1.235-0.1091Yes
150RPS12RPS12
Entrez,  Source
ribosomal protein S123149-1.236-0.0963Yes
151PSMD5PSMD5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 53166-1.275-0.0881Yes
152RPS28RPS28
Entrez,  Source
ribosomal protein S283187-1.329-0.0805Yes
153RPLP2RPLP2
Entrez,  Source
ribosomal protein, large, P23209-1.380-0.0727Yes
154RPS15ARPS15A
Entrez,  Source
ribosomal protein S15a3238-1.448-0.0664Yes
155RPL19RPL19
Entrez,  Source
ribosomal protein L193243-1.476-0.0524Yes
156RPS26RPS26
Entrez,  Source
ribosomal protein S263292-1.635-0.0503Yes
157RPS20RPS20
Entrez,  Source
ribosomal protein S203295-1.644-0.0339Yes
158TNKS1BP1TNKS1BP1
Entrez,  Source
tankyrase 1 binding protein 1, 182kDa3349-1.972-0.0299Yes
159RPS27RPS27
Entrez,  Source
ribosomal protein S27 (metallopanstimulin 1)3354-1.987-0.0106Yes
160RPLP1RPLP1
Entrez,  Source
ribosomal protein, large, P13377-2.4230.0077Yes
Table: GSEA details [plain text format]



Fig 2: REACTOME_METABOLISM_OF_MRNA: Random ES distribution   
Gene set null distribution of ES for REACTOME_METABOLISM_OF_MRNA