Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | chrom |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_neg |
| GeneSet | REACTOME_MEMBRANE_TRAFFICKING |
| Enrichment Score (ES) | -0.3935415 |
| Normalized Enrichment Score (NES) | -1.5601722 |
| Nominal p-value | 0.012594459 |
| FDR q-value | 0.0593639 |
| FWER p-Value | 0.792 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CLTA | CLTA Entrez, Source | clathrin, light chain (Lca) | 166 | 1.626 | -0.0067 | No |
| 2 | SEC31A | SEC31A Entrez, Source | SEC31 homolog A (S. cerevisiae) | 215 | 1.474 | 0.0179 | No |
| 3 | M6PR | M6PR Entrez, Source | mannose-6-phosphate receptor (cation dependent) | 394 | 1.094 | -0.0064 | No |
| 4 | VPS37B | VPS37B Entrez, Source | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 617 | 0.823 | -0.0510 | No |
| 5 | TFRC | TFRC Entrez, Source | transferrin receptor (p90, CD71) | 683 | 0.758 | -0.0504 | No |
| 6 | SEC24C | SEC24C Entrez, Source | SEC24 related gene family, member C (S. cerevisiae) | 741 | 0.702 | -0.0489 | No |
| 7 | AP3B1 | AP3B1 Entrez, Source | adaptor-related protein complex 3, beta 1 subunit | 877 | 0.599 | -0.0734 | No |
| 8 | OCRL | OCRL Entrez, Source | oculocerebrorenal syndrome of Lowe | 924 | 0.565 | -0.0722 | No |
| 9 | CHMP2A | CHMP2A Entrez, Source | chromatin modifying protein 2A | 1036 | 0.507 | -0.0920 | No |
| 10 | AP1M2 | AP1M2 Entrez, Source | adaptor-related protein complex 1, mu 2 subunit | 1097 | 0.462 | -0.0977 | No |
| 11 | RAB5C | RAB5C Entrez, Source | RAB5C, member RAS oncogene family | 1193 | 0.409 | -0.1153 | No |
| 12 | SNF8 | SNF8 Entrez, Source | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) | 1233 | 0.387 | -0.1167 | No |
| 13 | TPD52L1 | TPD52L1 Entrez, Source | tumor protein D52-like 1 | 1245 | 0.378 | -0.1100 | No |
| 14 | AP1B1 | AP1B1 Entrez, Source | adaptor-related protein complex 1, beta 1 subunit | 1402 | 0.279 | -0.1492 | No |
| 15 | TPD52 | TPD52 Entrez, Source | tumor protein D52 | 1448 | 0.247 | -0.1562 | No |
| 16 | SNAP23 | SNAP23 Entrez, Source | synaptosomal-associated protein, 23kDa | 1472 | 0.233 | -0.1569 | No |
| 17 | HSPA8 | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 1664 | 0.113 | -0.2109 | No |
| 18 | NAPA | NAPA Entrez, Source | N-ethylmaleimide-sensitive factor attachment protein, alpha | 1675 | 0.106 | -0.2111 | No |
| 19 | RPS27A | RPS27A Entrez, Source | ribosomal protein S27a | 1739 | 0.066 | -0.2282 | No |
| 20 | AP1S1 | AP1S1 Entrez, Source | adaptor-related protein complex 1, sigma 1 subunit | 1797 | 0.034 | -0.2443 | No |
| 21 | SEC13 | 1840 | 0.008 | -0.2566 | No | ||
| 22 | VAMP8 | VAMP8 Entrez, Source | vesicle-associated membrane protein 8 (endobrevin) | 2007 | -0.112 | -0.3032 | No |
| 23 | AP2M1 | AP2M1 Entrez, Source | adaptor-related protein complex 2, mu 1 subunit | 2008 | -0.113 | -0.3002 | No |
| 24 | AP1G1 | AP1G1 Entrez, Source | adaptor-related protein complex 1, gamma 1 subunit | 2014 | -0.114 | -0.2987 | No |
| 25 | DNM2 | DNM2 Entrez, Source | dynamin 2 | 2115 | -0.190 | -0.3235 | No |
| 26 | CLTC | CLTC Entrez, Source | clathrin, heavy chain (Hc) | 2121 | -0.198 | -0.3198 | No |
| 27 | COPB2 | COPB2 Entrez, Source | coatomer protein complex, subunit beta 2 (beta prime) | 2279 | -0.296 | -0.3589 | No |
| 28 | TSG101 | TSG101 Entrez, Source | tumor susceptibility gene 101 | 2285 | -0.299 | -0.3525 | No |
| 29 | STX4 | STX4 Entrez, Source | syntaxin 4 | 2346 | -0.332 | -0.3616 | No |
| 30 | CHMP6 | CHMP6 Entrez, Source | chromatin modifying protein 6 | 2454 | -0.424 | -0.3824 | Yes |
| 31 | VPS36 | VPS36 Entrez, Source | vacuolar protein sorting 36 (yeast) | 2457 | -0.428 | -0.3717 | Yes |
| 32 | PREB | PREB Entrez, Source | prolactin regulatory element binding | 2459 | -0.429 | -0.3606 | Yes |
| 33 | FTH1 | FTH1 Entrez, Source | ferritin, heavy polypeptide 1 | 2530 | -0.484 | -0.3688 | Yes |
| 34 | COPZ1 | COPZ1 Entrez, Source | coatomer protein complex, subunit zeta 1 | 2605 | -0.545 | -0.3765 | Yes |
| 35 | SEC24B | SEC24B Entrez, Source | SEC24 related gene family, member B (S. cerevisiae) | 2615 | -0.557 | -0.3645 | Yes |
| 36 | ARCN1 | ARCN1 Entrez, Source | archain 1 | 2629 | -0.570 | -0.3533 | Yes |
| 37 | HIP1R | HIP1R Entrez, Source | huntingtin interacting protein 1 related | 2690 | -0.615 | -0.3550 | Yes |
| 38 | COPA | COPA Entrez, Source | coatomer protein complex, subunit alpha | 2713 | -0.639 | -0.3448 | Yes |
| 39 | VAMP7 | 2751 | -0.666 | -0.3382 | Yes | ||
| 40 | VTA1 | 2775 | -0.709 | -0.3264 | Yes | ||
| 41 | VPS4B | VPS4B Entrez, Source | vacuolar protein sorting 4 homolog B (S. cerevisiae) | 2853 | -0.794 | -0.3285 | Yes |
| 42 | AP3S1 | AP3S1 Entrez, Source | adaptor-related protein complex 3, sigma 1 subunit | 2879 | -0.817 | -0.3144 | Yes |
| 43 | PICALM | PICALM Entrez, Source | phosphatidylinositol binding clathrin assembly protein | 2907 | -0.851 | -0.3000 | Yes |
| 44 | ARF1 | ARF1 Entrez, Source | ADP-ribosylation factor 1 | 3039 | -1.055 | -0.3113 | Yes |
| 45 | MYO6 | MYO6 Entrez, Source | myosin VI | 3040 | -1.055 | -0.2835 | Yes |
| 46 | CHMP4B | CHMP4B Entrez, Source | chromatin modifying protein 4B | 3128 | -1.194 | -0.2780 | Yes |
| 47 | TJP1 | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 3197 | -1.356 | -0.2625 | Yes |
| 48 | COPB1 | COPB1 Entrez, Source | coatomer protein complex, subunit beta 1 | 3240 | -1.454 | -0.2367 | Yes |
| 49 | VPS25 | VPS25 Entrez, Source | vacuolar protein sorting 25 homolog (S. cerevisiae) | 3244 | -1.477 | -0.1987 | Yes |
| 50 | SNX9 | SNX9 Entrez, Source | sorting nexin 9 | 3264 | -1.518 | -0.1643 | Yes |
| 51 | VPS28 | VPS28 Entrez, Source | vacuolar protein sorting 28 homolog (S. cerevisiae) | 3338 | -1.897 | -0.1361 | Yes |
| 52 | COPE | COPE Entrez, Source | coatomer protein complex, subunit epsilon | 3357 | -2.101 | -0.0860 | Yes |
| 53 | ARRB1 | ARRB1 Entrez, Source | arrestin, beta 1 | 3400 | -3.760 | 0.0006 | Yes |
