Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | chrom |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_pos |
| GeneSet | REACTOME_CELL_CYCLE_CHECKPOINTS |
| Enrichment Score (ES) | 0.443838 |
| Normalized Enrichment Score (NES) | 1.7195327 |
| Nominal p-value | 0.0016556291 |
| FDR q-value | 0.031762637 |
| FWER p-Value | 0.405 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 14 | 3.044 | 0.0593 | Yes |
| 2 | MCM2 | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 59 | 2.326 | 0.0947 | Yes |
| 3 | MCM3 | MCM3 Entrez, Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 70 | 2.223 | 0.1381 | Yes |
| 4 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 79 | 2.170 | 0.1809 | Yes |
| 5 | ORC1 | 94 | 2.080 | 0.2202 | Yes | ||
| 6 | MCM4 | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 105 | 2.044 | 0.2598 | Yes |
| 7 | MCM5 | MCM5 Entrez, Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 137 | 1.781 | 0.2877 | Yes |
| 8 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 169 | 1.622 | 0.3122 | Yes |
| 9 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 234 | 1.421 | 0.3226 | Yes |
| 10 | PSME2 | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 238 | 1.412 | 0.3512 | Yes |
| 11 | MAD1L1 | MAD1L1 Entrez, Source | MAD1 mitotic arrest deficient-like 1 (yeast) | 249 | 1.390 | 0.3772 | Yes |
| 12 | PSME1 | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 340 | 1.183 | 0.3749 | Yes |
| 13 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 447 | 1.003 | 0.3640 | Yes |
| 14 | CDK1 | 472 | 0.977 | 0.3771 | Yes | ||
| 15 | PSMB10 | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 474 | 0.974 | 0.3972 | Yes |
| 16 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 494 | 0.950 | 0.4113 | Yes |
| 17 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 511 | 0.930 | 0.4259 | Yes |
| 18 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 594 | 0.851 | 0.4191 | Yes |
| 19 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 595 | 0.851 | 0.4368 | Yes |
| 20 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 664 | 0.772 | 0.4325 | Yes |
| 21 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 680 | 0.759 | 0.4438 | Yes |
| 22 | RFC5 | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 764 | 0.685 | 0.4332 | No |
| 23 | PSMB4 | PSMB4 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 4 | 780 | 0.674 | 0.4427 | No |
| 24 | ORC5 | 958 | 0.546 | 0.4010 | No | ||
| 25 | ORC3 | 971 | 0.538 | 0.4086 | No | ||
| 26 | PSMC3 | PSMC3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 1014 | 0.515 | 0.4067 | No |
| 27 | ANAPC5 | ANAPC5 Entrez, Source | anaphase promoting complex subunit 5 | 1103 | 0.459 | 0.3899 | No |
| 28 | PSMB6 | PSMB6 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 6 | 1117 | 0.450 | 0.3954 | No |
| 29 | PSMA5 | PSMA5 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 1120 | 0.447 | 0.4041 | No |
| 30 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 1169 | 0.419 | 0.3984 | No |
| 31 | PSMB2 | PSMB2 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 2 | 1243 | 0.379 | 0.3844 | No |
| 32 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 1280 | 0.355 | 0.3810 | No |
| 33 | ORC2 | 1298 | 0.346 | 0.3831 | No | ||
| 34 | PSMA6 | PSMA6 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 6 | 1398 | 0.283 | 0.3593 | No |
| 35 | PSMA3 | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 1487 | 0.225 | 0.3375 | No |
| 36 | ANAPC1 | ANAPC1 Entrez, Source | anaphase promoting complex subunit 1 | 1498 | 0.217 | 0.3391 | No |
| 37 | CDC16 | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 1512 | 0.203 | 0.3394 | No |
| 38 | PSMA4 | PSMA4 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 1518 | 0.200 | 0.3421 | No |
| 39 | PSMB1 | PSMB1 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 1 | 1571 | 0.168 | 0.3300 | No |
| 40 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 1604 | 0.149 | 0.3235 | No |
| 41 | PSMB3 | PSMB3 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 3 | 1731 | 0.073 | 0.2871 | No |
| 42 | RPS27A | RPS27A Entrez, Source | ribosomal protein S27a | 1739 | 0.066 | 0.2864 | No |
| 43 | PSMC6 | PSMC6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 1759 | 0.054 | 0.2818 | No |
| 44 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 1770 | 0.048 | 0.2798 | No |
| 45 | PSMC5 | PSMC5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 1784 | 0.038 | 0.2767 | No |
| 46 | PSMA1 | PSMA1 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 1 | 1811 | 0.028 | 0.2695 | No |
| 47 | PSMD14 | PSMD14 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 1832 | 0.013 | 0.2638 | No |
| 48 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 1857 | -0.004 | 0.2566 | No |
| 49 | PSMA2 | PSMA2 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 2 | 1911 | -0.047 | 0.2417 | No |
| 50 | PSMC4 | PSMC4 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 2015 | -0.115 | 0.2132 | No |
| 51 | PSMD6 | PSMD6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 2028 | -0.127 | 0.2122 | No |
| 52 | PSMD1 | PSMD1 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 2033 | -0.133 | 0.2138 | No |
| 53 | PSMD11 | PSMD11 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 2082 | -0.168 | 0.2029 | No |
| 54 | PSMD2 | PSMD2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 2091 | -0.175 | 0.2041 | No |
| 55 | PSMB7 | PSMB7 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 7 | 2141 | -0.209 | 0.1938 | No |
| 56 | MAD2L1 | MAD2L1 Entrez, Source | MAD2 mitotic arrest deficient-like 1 (yeast) | 2160 | -0.220 | 0.1929 | No |
| 57 | PSMC1 | PSMC1 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 2163 | -0.220 | 0.1969 | No |
| 58 | PSMA7 | PSMA7 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 2167 | -0.223 | 0.2007 | No |
| 59 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 2182 | -0.233 | 0.2013 | No |
| 60 | PSMD3 | PSMD3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 2216 | -0.256 | 0.1968 | No |
| 61 | ANAPC7 | ANAPC7 Entrez, Source | anaphase promoting complex subunit 7 | 2231 | -0.267 | 0.1981 | No |
| 62 | PSMD12 | PSMD12 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 2232 | -0.268 | 0.2037 | No |
| 63 | PSMD13 | PSMD13 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 2239 | -0.272 | 0.2076 | No |
| 64 | ANAPC10 | ANAPC10 Entrez, Source | anaphase promoting complex subunit 10 | 2259 | -0.286 | 0.2078 | No |
| 65 | PSMD7 | PSMD7 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) | 2311 | -0.312 | 0.1990 | No |
| 66 | PSMB5 | PSMB5 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 5 | 2356 | -0.336 | 0.1928 | No |
| 67 | PSMD8 | PSMD8 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 2368 | -0.349 | 0.1968 | No |
| 68 | PSMD4 | PSMD4 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 2456 | -0.426 | 0.1796 | No |
| 69 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 2509 | -0.467 | 0.1737 | No |
| 70 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 2639 | -0.577 | 0.1470 | No |
| 71 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 2655 | -0.591 | 0.1548 | No |
| 72 | PSMD10 | PSMD10 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 3006 | -0.992 | 0.0703 | No |
| 73 | UBE2E1 | UBE2E1 Entrez, Source | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 3030 | -1.026 | 0.0848 | No |
| 74 | PSMD5 | PSMD5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 3166 | -1.275 | 0.0709 | No |
