Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | chrom |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_neg |
| GeneSet | REACTOME_AXON_GUIDANCE |
| Enrichment Score (ES) | -0.39348537 |
| Normalized Enrichment Score (NES) | -1.5883113 |
| Nominal p-value | 0.007894737 |
| FDR q-value | 0.04973446 |
| FWER p-Value | 0.72 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | AP2A2 | AP2A2 Entrez, Source | adaptor-related protein complex 2, alpha 2 subunit | 143 | 1.757 | -0.0027 | No |
| 2 | KIF4A | KIF4A Entrez, Source | kinesin family member 4A | 154 | 1.686 | 0.0327 | No |
| 3 | CLTA | CLTA Entrez, Source | clathrin, light chain (Lca) | 166 | 1.626 | 0.0665 | No |
| 4 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 193 | 1.555 | 0.0941 | No |
| 5 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 198 | 1.523 | 0.1276 | No |
| 6 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 330 | 1.198 | 0.1158 | No |
| 7 | CDK1 | 472 | 0.977 | 0.0959 | No | ||
| 8 | CREB1 | CREB1 Entrez, Source | cAMP responsive element binding protein 1 | 503 | 0.943 | 0.1084 | No |
| 9 | STIP1 | STIP1 Entrez, Source | stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) | 658 | 0.781 | 0.0802 | No |
| 10 | CSNK2B | CSNK2B Entrez, Source | casein kinase 2, beta polypeptide | 714 | 0.726 | 0.0803 | No |
| 11 | TLN1 | TLN1 Entrez, Source | talin 1 | 719 | 0.721 | 0.0955 | No |
| 12 | MSN | MSN Entrez, Source | moesin | 1006 | 0.520 | 0.0219 | No |
| 13 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 1105 | 0.459 | 0.0030 | No |
| 14 | HSP90AA1 | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 1531 | 0.190 | -0.1197 | No |
| 15 | RPS6KA4 | RPS6KA4 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 1595 | 0.157 | -0.1349 | No |
| 16 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 1699 | 0.091 | -0.1636 | No |
| 17 | CDK5 | CDK5 Entrez, Source | cyclin-dependent kinase 5 | 1709 | 0.082 | -0.1644 | No |
| 18 | ARHGAP35 | 1725 | 0.076 | -0.1672 | No | ||
| 19 | PAK4 | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 1750 | 0.056 | -0.1731 | No |
| 20 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 1837 | 0.011 | -0.1985 | No |
| 21 | RDX | RDX Entrez, Source | radixin | 1885 | -0.025 | -0.2120 | No |
| 22 | RHOC | RHOC Entrez, Source | ras homolog gene family, member C | 1896 | -0.032 | -0.2143 | No |
| 23 | AP2A1 | AP2A1 Entrez, Source | adaptor-related protein complex 2, alpha 1 subunit | 1908 | -0.044 | -0.2166 | No |
| 24 | HSP90AB1 | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 1925 | -0.057 | -0.2201 | No |
| 25 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 1977 | -0.088 | -0.2333 | No |
| 26 | YWHAB | YWHAB Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 1989 | -0.098 | -0.2343 | No |
| 27 | AP2M1 | AP2M1 Entrez, Source | adaptor-related protein complex 2, mu 1 subunit | 2008 | -0.113 | -0.2372 | No |
| 28 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 2018 | -0.116 | -0.2372 | No |
| 29 | AP2S1 | AP2S1 Entrez, Source | adaptor-related protein complex 2, sigma 1 subunit | 2026 | -0.126 | -0.2364 | No |
| 30 | DNM2 | DNM2 Entrez, Source | dynamin 2 | 2115 | -0.190 | -0.2584 | No |
| 31 | CLTC | CLTC Entrez, Source | clathrin, heavy chain (Hc) | 2121 | -0.198 | -0.2554 | No |
| 32 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 2123 | -0.200 | -0.2511 | No |
| 33 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 2140 | -0.209 | -0.2512 | No |
| 34 | PFN1 | PFN1 Entrez, Source | profilin 1 | 2241 | -0.273 | -0.2748 | No |
| 35 | EZR | 2394 | -0.370 | -0.3118 | No | ||
| 36 | CSNK2A2 | CSNK2A2 Entrez, Source | casein kinase 2, alpha prime polypeptide | 2435 | -0.404 | -0.3146 | No |
| 37 | AP2B1 | AP2B1 Entrez, Source | adaptor-related protein complex 2, beta 1 subunit | 2437 | -0.407 | -0.3056 | No |
| 38 | RANBP9 | RANBP9 Entrez, Source | RAN binding protein 9 | 2462 | -0.430 | -0.3030 | No |
| 39 | SPTBN2 | SPTBN2 Entrez, Source | spectrin, beta, non-erythrocytic 2 | 2495 | -0.455 | -0.3022 | No |
| 40 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2497 | -0.456 | -0.2921 | No |
| 41 | RRAS | RRAS Entrez, Source | related RAS viral (r-ras) oncogene homolog | 2640 | -0.577 | -0.3214 | No |
| 42 | RPS6KA1 | RPS6KA1 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2662 | -0.595 | -0.3141 | No |
| 43 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 2684 | -0.609 | -0.3065 | No |
| 44 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 2804 | -0.735 | -0.3253 | No |
| 45 | RHOG | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 2918 | -0.866 | -0.3394 | No |
| 46 | ANK3 | ANK3 Entrez, Source | ankyrin 3, node of Ranvier (ankyrin G) | 3100 | -1.143 | -0.3675 | Yes |
| 47 | SPTAN1 | SPTAN1 Entrez, Source | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | 3138 | -1.214 | -0.3509 | Yes |
| 48 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 3180 | -1.309 | -0.3333 | Yes |
| 49 | SPTBN1 | SPTBN1 Entrez, Source | spectrin, beta, non-erythrocytic 1 | 3205 | -1.374 | -0.3092 | Yes |
| 50 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 3214 | -1.393 | -0.2798 | Yes |
| 51 | VASP | VASP Entrez, Source | vasodilator-stimulated phosphoprotein | 3265 | -1.518 | -0.2602 | Yes |
| 52 | MYL6 | MYL6 Entrez, Source | myosin, light chain 6, alkali, smooth muscle and non-muscle | 3340 | -1.922 | -0.2385 | Yes |
| 53 | ARHGEF12 | ARHGEF12 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 12 | 3345 | -1.954 | -0.1952 | Yes |
| 54 | ABLIM1 | ABLIM1 Entrez, Source | actin binding LIM protein 1 | 3346 | -1.956 | -0.1506 | Yes |
| 55 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 3353 | -1.984 | -0.1072 | Yes |
| 56 | MYH14 | MYH14 Entrez, Source | myosin, heavy chain 14 | 3362 | -2.145 | -0.0608 | Yes |
| 57 | ENAH | ENAH Entrez, Source | enabled homolog (Drosophila) | 3395 | -3.178 | 0.0021 | Yes |
