CoV Genome Tracker

《冠状病毒基因组进化浏览器》简介

http://cov.borreliebase.org

• Outbreaks (微进化)
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Haplotype networks
This tab shows diversity of viral genomes & their rapid evolution during global spread. Nodes represent distinct haplotypes. Slices within a colored node represent individual patients. Uncolored nodes are hypothetical. Each link represents one nucleotide change.

病毒基因组单倍型进化图
该页显示病毒基因组多态性,以及传播期间的快速进化。每个结点代表一种单倍型。彩色结点中的每个扇形为一个病例;未着色结点为假设过渡态。结点间连线代表单个碱基变异。
• Evolution (宏进化)
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Genome phylogeny of isolates, collection year & location, PubMed links, and a map of China (from left to right).
This tab shows that, most likely, the SARS outbreak in 2003-2004 and the Covid-19 outbreak in 2019-2020 are two seperate spillover events from bats.

病毒分离株的进化树、分离时间和地点、文献链结及地理分布
该页表明,2003-2004年的SARS疫情和2019-2020年的新冠病毒疫情,是两个独立事件,但都可追溯到蝙蝠。
• Genome page (基因组比较)
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Genome tracks and sequence evolutionary rates by codon positions.
This tab shows similar viral genome structures but very different evolutionary rates among viral genes. The S protein locus is the fastest-evolving gene as well as a recombination hotspot.

病毒全基因组和分子进化速度
该页显示,冠状病毒基因结构高度保守相似,但基因序列的进化速度因基因而异。S蛋白基因位点的进化速度最快,而且是病毒重组和遗传杂交的热点。
• Gene page (基因序列比较)
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Phylogeny & sequence alignments of a single gene.
This tab shows a gene tree and helps compare nucleotide and amino acid sequence similarities and differences at a gene locus. (A dot represents the same as the first sequence. A blank represents an alignment gap.)

单个基因进化树及序列比对
该页显示单个基因的进化树,以及病毒分离株之间核苷酸和氨基酸序列的异同。(黑点表示与首条序列一致)

Acknowledgement: Members of Qiu Lab at City University of New York, Hunter College
秋 笛   二零二零年三月十一日   美国纽约秋园